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伊万·马莱克的连续培养概念对生物加工的影响。

The impact of Ivan Málek's continuous culture concept on bioprocessing.

机构信息

Institute of Microbiology ASCR, v.v.i, Prague, Czech Republic.

出版信息

J Ind Microbiol Biotechnol. 2010 Dec;37(12):1249-56. doi: 10.1007/s10295-010-0881-8. Epub 2010 Nov 18.

DOI:10.1007/s10295-010-0881-8
PMID:21086100
Abstract

This paper summarizes research results and their industrial applications obtained by continuous culture in the former Czechoslovakia. Past achievements as well as recent trends and developments worldwide are presented. The term "Prague School of continuous culture" is put forward and its international activity is outlined. The impact of this school was pervasive across the entire field of applied microbiology and biotechnology in Czechoslovakia and, perhaps, even beyond the country's borders. Continuous culture is a very mature field, and since its establishment it has become a powerful research tool. The present activity in this field amounts to a renaissance of continuous culture, emphasizing new dimensions in bioinformatics and systems biology.

摘要

本文总结了前捷克斯洛伐克通过连续培养获得的研究成果及其工业应用。介绍了过去的成就以及全球近期的趋势和发展。提出了“布拉格连续培养学派”这一术语，并概述了其国际活动。该学派的影响遍及捷克斯洛伐克应用微生物学和生物技术的整个领域，也许甚至超出了国界。连续培养是一个非常成熟的领域，自建立以来，它已成为一种强大的研究工具。目前该领域的活动是连续培养的复兴，强调了生物信息学和系统生物学的新维度。

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