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[心肌梗死后乳头肌断裂的二尖瓣置换术。关于梗死急性期手术治疗的13例报告]

[Mitral valve replacement in post-infarction rupture of the papillary muscle. Apropos of 13 cases surgically treated during the acute phase of infarction].

作者信息

Defraigne J O, Lavigne J P, Remy D, Dekoster G, Limet R

机构信息

Service de chirurgie cardio-vasculaire et thoracique, Centre hospitalier universitaire du Sart-Tilman, B 33, Liège, Belgique.

出版信息

Arch Mal Coeur Vaiss. 1990 Mar;83(3):377-82.

PMID:2108632
Abstract

Between 1983 and 1988, thirteen patients (12 men and 1 women, average age 63 years) were operated in the acute phase of myocardial infarction for papillary muscle rupture (PMR). The rupture involved the posterior papillary muscle in 12 cases. The average left ventricular ejection fraction was 47 +/- 9 per cent (range 34 to 63%). Pulmonary capillary pressures ranged from 76 to 41 mmHg (average 35 mmHg). Eleven patients presented with acute pulmonary oedema and 7 had cardiogenic shock. Coronary arteriography showed triple vessel disease in 3 cases, double vessel disease in 7 cases and single vessel disease in 3 cases. Surgery was carried out on average 2.7 days after the rupture and 10 days after the initial infarct. In addition to mitral valve replacement (N = 13), 11 patients underwent a myocardial revascularisation procedure. The operative mortality was 15 per cent (N = 2). Papillary muscle rupture in the acute phase of myocardial infarction causes cardiac failure which is related more to the mechanical abnormality than to an alteration of left ventricular function. Considering the operative mortality and the natural history of PMR treated medically, the authors recommend early surgery as the only management which can improve the precarious haemodynamic status of patients with this complication.

摘要

1983年至1988年间,13例患者(12名男性和1名女性,平均年龄63岁)在心肌梗死急性期因乳头肌破裂(PMR)接受手术。12例破裂累及后乳头肌。平均左心室射血分数为47±9%(范围34%至63%)。肺毛细血管压力范围为76至41 mmHg(平均35 mmHg)。11例患者出现急性肺水肿,7例发生心源性休克。冠状动脉造影显示3例为三支血管病变,7例为双支血管病变,3例为单支血管病变。手术平均在破裂后2.7天和初次梗死10天后进行。除二尖瓣置换术(N = 13)外,11例患者还接受了心肌血运重建术。手术死亡率为15%(N = 2)。心肌梗死急性期的乳头肌破裂导致心力衰竭,这更多地与机械异常有关,而非左心室功能改变。考虑到手术死亡率和药物治疗PMR的自然病程,作者建议早期手术是改善该并发症患者不稳定血流动力学状态的唯一治疗方法。

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