Department of Medical Gerontology, Trinity College Dublin, Ireland.
Int J Geriatr Psychiatry. 2010 Dec;25(12):1288-95. doi: 10.1002/gps.2482.
Depression and anxiety are the most common mood symptoms and psychological consequences of stroke. This study aimed to examine the influence of acute depression and anxiety symptoms on functional recovery and health-related quality of life (HRQoL) one year after stroke.
At one month and one year after stroke, the prevalence and severity of depression and anxiety symptoms were examined in consecutively admitted patients, using the Hospital Anxiety and Depression Scale (HADS). Functional recovery was assessed using the Nottingham Extended Activities of Daily Living (NEADL) and HRQoL using the Stroke-Specific Quality of Life scale (SSQOL).
In 107 patients, the prevalence of depression and anxiety symptoms was 35% at one month and 36% and 34%, respectively, at one year. Depression symptoms were significantly associated with functional ability (r = -0.19, p < 0.05) and HRQoL (r = -0.41, p < 0.001) at one year. Anxiety symptoms were significantly associated with HRQoL (r = -0.33, p < 0.001) only. Multivariate analyses indicated that both depression (β = -0.33, p < 0.001) and anxiety (β = -0.26, p < 0.01) symptoms explained some variance in HRQoL at one month and did not predict functional recovery or HRQoL at one year, after controlling for other independent variables such as stroke severity and pre-morbid conditions.
Mood symptoms following acute stroke were associated with a poorer HRQoL one year later but only depression symptoms influenced functional recovery. Other clinical factors such as pre-morbid conditions may need to be taken into consideration when determining the effect of mood symptoms on stroke recovery.
抑郁和焦虑是中风后最常见的情绪症状和心理后果。本研究旨在探讨急性抑郁和焦虑症状对中风后一年功能恢复和健康相关生活质量（HRQoL）的影响。
在中风后一个月和一年时，使用医院焦虑和抑郁量表（HADS）连续评估入院患者的抑郁和焦虑症状的患病率和严重程度。使用诺丁汉扩展日常生活活动量表（NEADL）评估功能恢复，使用中风特异性生活质量量表（SSQOL）评估 HRQoL。
在 107 名患者中，一个月时抑郁和焦虑症状的患病率分别为 35%和 36%，一年时分别为 34%。抑郁症状与一年时的功能能力（r = -0.19，p < 0.05）和 HRQoL（r = -0.41，p < 0.001）显著相关。焦虑症状仅与 HRQoL 显著相关（r = -0.33，p < 0.001）。多变量分析表明，抑郁（β = -0.33，p < 0.001）和焦虑（β = -0.26，p < 0.01）症状在控制其他独立变量（如中风严重程度和发病前状况）后，一个月时可解释部分 HRQoL 的差异，但一年时不能预测功能恢复或 HRQoL。
急性中风后的情绪症状与一年后较差的 HRQoL 相关，但只有抑郁症状影响功能恢复。在确定情绪症状对中风恢复的影响时，可能需要考虑其他临床因素，如发病前状况。
