Shpeĭzer G M, Khutorianskiĭ V A, Smirnov A I, Rodionova V A, Mineeva L A, Iushkov G G, Malyshkina N A, Igumen'sheva V V, Shchukina O G
Vopr Kurortol Fizioter Lech Fiz Kult. 2010 Jul-Aug(4):41-2.
A new technology for isolation of medicinal balneological preparations from mineral waters has been developed. It is based on the extraction of biologically active compounds (BAC) from mineral waters with ethanol following oxidative hydrolysis and water vapour distillation. This technology has no analogs both in this country and abroad. Unlike ordinary balneological medicines, those obtained by the new method do not contain inorganic matrix, show higher activity, and remain stable for a longer period. The primary composition of BACs isolated by the above technology was studied using solid-phase extraction and chromatomass-spectrometry. Analysis of Extramine, a medicinal preparation from Novonukutskaya hydrogen sulfide mineral water (Siberian Matsesta), allowed to identify active components responsible for its therapeutic effects and elucidate mechanisms of their action. The 15-year-long experience with practical application of BACs obtained with the help of the new technology has demonstrated that they possesses antiallergic, antiviral, and analeptic activities. These compounds increase general resistance of the organism to infection, promote removal of toxic substances, accelerate wound and injury healing, and prevent the development of herpes infection.
已研发出一种从矿泉水中分离药用浴用制剂的新技术。该技术基于在氧化水解和水蒸气蒸馏后用乙醇从矿泉水中提取生物活性化合物（BAC）。此技术在国内外均无类似技术。与普通浴用药物不同，通过新方法获得的药物不含无机基质，活性更高，且能在更长时间内保持稳定。使用固相萃取和色谱 - 质谱联用技术研究了通过上述技术分离出的BAC的主要成分。对来自新努库茨卡亚硫化氢矿泉水（西伯利亚马特塞斯塔）的药用制剂Extramine进行分析，有助于确定其治疗作用的活性成分并阐明其作用机制。借助新技术获得的BAC长达15年的实际应用经验表明，它们具有抗过敏、抗病毒和兴奋作用。这些化合物可增强机体对感染的总体抵抗力，促进有毒物质的清除，加速伤口和损伤愈合，并预防疱疹感染的发生。
