Laukkarinen Johanna, Sand Juhani, Nordback Isto
TAYS, gastroenterologian vastuualue, Teiskontie 35 33521, Tampere.
Duodecim. 2010;126(19):2247-52.
For decades, one well-known risk factor for the development of gallbladder stones has been hypothyroidism. Recent studies have reported that the risk for common bile duct stones particularly increases both in clinical and subclinical hypothyroidism. There are multiple factors that may contribute to the formation and/or accumulation of common bile duct stones in hypothyroid patients, including decreased liver cholesterol metabolism, diminished bile secretion, and reduced sphincter of Oddi relaxation. When treating patients with common bile duct stones or microlithiasis, the clinicians should be aware of the possible hypothyroid background, and consider the need for thyroid function assessment in these patients.
几十年来,甲状腺功能减退一直是胆囊结石形成的一个众所周知的风险因素。最近的研究报告称,无论是临床还是亚临床甲状腺功能减退,胆总管结石的风险都会显著增加。甲状腺功能减退患者胆总管结石的形成和/或积聚可能由多种因素导致,包括肝脏胆固醇代谢降低、胆汁分泌减少以及Oddi括约肌松弛度降低。在治疗胆总管结石或微结石患者时,临床医生应注意可能存在的甲状腺功能减退背景,并考虑对这些患者进行甲状腺功能评估。