Involvement of protein kinase C in the regulation of assembly-disassembly of neurofilaments in vitro.
作者信息
Gonda Y, Nishizawa K, Ando S, Kitamura S, Minoura Y, Nishi Y, Inagaki M
机构信息
Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Nagoya, Japan.
出版信息
Biochem Biophys Res Commun. 1990 Mar 30;167(3):1316-25. doi: 10.1016/0006-291x(90)90667-c.
PMID:2108674
Abstract
Protein kinase C phosphorylated the major mammalian neurofilament protein (NF-L) with approximately 3 mol phosphate per mol protein. The phosphorylated NF-L no longer formed the filaments. Sequential analysis of the tryptic phosphopeptides, together with the known primary sequence, revealed that Ser-12, Ser-27, Ser-33 and Ser-51 were phosphorylated by protein kinase C. These findings contribute toward elucidation of mechanisms regulating the functions of neurofilaments.
摘要
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