Natukunda Eva, Musiime Victor, Ssali Francis, Kizito Hilda, Kityo Cissy, Mugyenyi Peter
Joint Clinical Research Centre , Kampala, Uganda.
AIDS Res Hum Retroviruses. 2011 Apr;27(4):373-6. doi: 10.1089/aid.2010.0167. Epub 2010 Nov 18.
An 8-year-old HIV-positive antiretroviral therapy-naive child developed severe headache and generalized lymphadenopathy. The serum cryptococcal antigen (CRAG) test was positive, the histology on the lymph node biopsy revealed budding yeast cells, and Cryptococcus neoformans was isolated on culture of his cerebrospinal fluid. He was treated with intravenous amphotericin B followed by oral fluconazole with a good response. Therefore cryptococcal lymphadenitis should be considered in the differential diagnosis of children presenting with lymphadenopathy and a positive serum CRAG.
一名8岁未接受过抗逆转录病毒治疗的HIV阳性儿童出现严重头痛和全身淋巴结病。血清隐球菌抗原（CRAG）检测呈阳性，淋巴结活检的组织学检查显示出芽酵母细胞，其脑脊液培养分离出新型隐球菌。他接受了静脉注射两性霉素B治疗，随后口服氟康唑，反应良好。因此，在对出现淋巴结病且血清CRAG阳性的儿童进行鉴别诊断时，应考虑隐球菌性淋巴结炎。
