MacMahon R A, Frampton R J, Yardley R W
Monash University, Department of Paediatrics, Monash Medical Centre, Melbourne, Australia.
Biol Neonate. 1990;57(3-4):231-7. doi: 10.1159/000243196.
The common clinical practice of intravenous feeding of the pregnant woman poses the question of the effect on the fetus of such infusions. We have used the sheep as a model to study the change in fetal amino acid levels after a maternal infusion of Synthamin 13. The maternal plasma aminogram largely reflects the amino acid pattern in the infusate. However, in the fetal circulation only the branched chain amino acids (leucine, isoleucine and valine), phenylalanine and alanine rose significantly after infusion. Only leucine and isoleucine were observed to spill into the fetal urine. The results suggest that the ovine placenta selectively modifies the amino acid profile presented to the fetus when the maternal plasma aminogram is distorted. However, the fetus is not totally protected from changes in phenylalanine, which in high concentrations, is detrimental to normal development.
对孕妇进行静脉营养的常见临床操作引发了此类输注对胎儿影响的问题。我们以绵羊为模型，研究母体输注13种复合结晶氨基酸注射液后胎儿氨基酸水平的变化。母体血浆氨基酸谱很大程度上反映了输注液中的氨基酸模式。然而，输注后胎儿循环中只有支链氨基酸（亮氨酸、异亮氨酸和缬氨酸）、苯丙氨酸和丙氨酸显著升高。仅观察到亮氨酸和异亮氨酸排入胎儿尿液。结果表明，当母体血浆氨基酸谱发生改变时，绵羊胎盘会选择性地改变输送给胎儿的氨基酸谱。然而，胎儿并不能完全免受苯丙氨酸变化的影响，高浓度的苯丙氨酸对正常发育有害。
