Département de Neurologie, Centre Hospitalier Régional Universitaire de Strasbourg, Strasbourg, France.
Eur J Neurol. 2011 Jun;18(6):836-41. doi: 10.1111/j.1468-1331.2010.03252.x. Epub 2010 Nov 18.
The burden of multiple sclerosis (MS) includes fatigue, depression and worsening of health-related quality of life (HRQOL). These changes have not been yet measured in neuromyelitis optica (NMO). Our aim was to assess the HRQOL, fatigue and depression in NMO.
We administered French validated self-questionnaires on HRQOL (SEP-59), fatigue (EMIF-SEP) and depression (EHD) to 40 patients followed up in two centres. We assessed the relationship of these parameters with gender, age, disability, disease duration, visual acuity and NMO-antibody status and also compared our results with equivalent data in MS and normal subjects derived from previous studies.
Health-related quality of life scores were lower (P < 0.01) in patients with NMO when compared to normal subjects. No significant difference was noted between patients with NMO and MS for most scores, the exceptions being HRQOL related to cognitive function (better in NMO than in MS), HRQOL related to sphincter dysfunction (worse in NMO than in MS) and the psychological dimension of fatigue (milder in NMO than in MS). Disability was the main predictive factor of an unfavourable evolution.
This study reveals the strong impact of NMO on HRQOL, fatigue and depression and the importance of screening patients, especially the more disabled, so as to initiate suitable treatment.
多发性硬化症（MS）的负担包括疲劳、抑郁和健康相关生活质量（HRQOL）恶化。这些变化尚未在视神经脊髓炎（NMO）中进行测量。我们的目的是评估 NMO 的 HRQOL、疲劳和抑郁。
我们在两个中心对 40 名患者进行了法国验证的自我问卷评估，包括 HRQOL（SEP-59）、疲劳（EMIF-SEP）和抑郁（EHD）。我们评估了这些参数与性别、年龄、残疾、疾病持续时间、视力和 NMO 抗体状态的关系，并将我们的结果与来自先前研究的 MS 和正常受试者的等效数据进行了比较。
与正常受试者相比，NMO 患者的健康相关生活质量评分较低（P < 0.01）。NMO 患者与 MS 患者之间的大多数评分没有显著差异，例外是与认知功能相关的 HRQOL（NMO 优于 MS）、与括约肌功能障碍相关的 HRQOL（NMO 比 MS 更差）和疲劳的心理维度（NMO 比 MS 更温和）。残疾是不利预后的主要预测因素。
这项研究揭示了 NMO 对 HRQOL、疲劳和抑郁的强烈影响，以及对患者进行筛查的重要性，特别是对残疾程度更高的患者，以便开始适当的治疗。
