Department of Hematology, University of Crete School of Medicine, Heraklion, Crete, Greece.
Leuk Res. 2011 Mar;35(3):413-5. doi: 10.1016/j.leukres.2010.10.023. Epub 2010 Nov 18.
Alterations of the ten-eleven translocation-2 (TET2) gene have been recently identified in patients with myeloid malignancies using molecular, comparative genomic hybridization and single nucleotide polymorphism array techniques. We have performed TET2 fluorescence in situ hybridization analysis in a cohort of patients with myeloid disorders including myeloid malignancies and chronic idiopathic neutropenia, aiming to determine the usefulness of the technique in the identification of TET2 gene alterations. A TET2 deletion was found in one patient with chronic myelomonocytic leukemia suggesting that fluorescence in situ hybridization may have a role in identification of TET2 deletions, at least in this group of patients.
最近，使用分子、比较基因组杂交和单核苷酸多态性微阵列技术，在患有髓系恶性肿瘤的患者中发现了十号染色体十一号易位-2（TET2）基因的改变。我们对包括髓系恶性肿瘤和慢性特发性中性粒细胞减少症在内的髓系疾病患者进行了 TET2 荧光原位杂交分析，旨在确定该技术在鉴定 TET2 基因改变中的有用性。在一名慢性粒单核细胞白血病患者中发现了 TET2 缺失，这表明荧光原位杂交可能至少在这组患者中有助于鉴定 TET2 缺失。
