Departamento de Farmacobiologia, Cinvestav, IPN Calzada de los Tenorios 235, Col. Granjas Coapa, Mexico, D.F. 14330, Mexico.
J Neuroimmunol. 2011 Mar;232(1-2):101-7. doi: 10.1016/j.jneuroim.2010.10.017. Epub 2010 Nov 17.
To characterize immunosuppressive effects of morphine on the early innate immunity response of cytokine production in peritoneal cavity after LPS challenge.
The effects of a single i.p. administration of morphine (3.1 or 31 mg/kg) on LPS-induced tumor necrosis factor α (TNF-α) and monocyte chemoattractant protein-1 (CCL2) intraperitoneal release was tested in Swiss-Webster, C57BL/6J, mast cell deficient Kit(Wsh/Wsh) (W-sh) and mast cell reconstituted (W-sh-rec) mice.
Morphine was found to inhibit LPS-induced TNF-α but not CCL2 release in the peritoneal cavity. Studies on mast cell deficient and reconstituted mice indicate that resident mast cells mediate selective morphine immunosuppression in the peritoneal cavity.
描述吗啡对脂多糖刺激后腹腔早期先天免疫反应细胞因子产生的免疫抑制作用。
研究人员通过单次腹腔注射吗啡（3.1 或 31mg/kg），测试其对瑞士-韦伯斯特、C57BL/6J、肥大细胞缺陷型 Kit(Wsh/Wsh)（W-sh）和肥大细胞重建（W-sh-rec）小鼠腹腔内脂多糖诱导的肿瘤坏死因子-α（TNF-α）和单核细胞趋化蛋白-1（CCL2）释放的影响。
研究发现，吗啡抑制了 LPS 诱导的 TNF-α，但不抑制 CCL2 在腹腔内的释放。对肥大细胞缺陷和重建小鼠的研究表明，驻留肥大细胞介导了吗啡对腹腔的选择性免疫抑制作用。
