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促甲状腺激素释放激素(TRH)对舌下运动神经元的兴奋作用。

Excitatory effects of thyrotropin-releasing hormone (TRH) in hypoglossal motoneurons.

作者信息

Rekling J C

机构信息

Institute of Neurophysiology, Copenhagen University, Denmark.

出版信息

Brain Res. 1990 Feb 26;510(1):175-9. doi: 10.1016/0006-8993(90)90749-2.

Abstract

The effect of thyrotropin-releasing hormone (TRH) was studied in 30 hypoglossal motoneurons from brainstem slices of guinea pigs. Bath application of TRH resulted in an increase of the spontaneous excitatory synaptic activity, depolarization of the neurons, increase of the input resistance and change of the duration of the falling phase of excitatory postsynaptic potentials. The depolarizing response and membrane conductance change was the result of a direct postsynaptic action of TRH, possibly mediated by a reduction of a potassium conductance.

摘要

在豚鼠脑干切片的30个舌下运动神经元中研究了促甲状腺激素释放激素(TRH)的作用。浴槽中应用TRH导致自发兴奋性突触活动增加、神经元去极化、输入电阻增加以及兴奋性突触后电位下降相持续时间改变。去极化反应和膜电导变化是TRH直接突触后作用的结果,可能是由钾电导降低介导的。

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