Bioinorganic and Environmental Analytical Chemistry Laboratory, Chemistry Department, Faculty of Basic Science, University of Antofagasta, Antofagasta, Chile.
Hum Exp Toxicol. 2011 Sep;30(9):1150-64. doi: 10.1177/0960327110389835. Epub 2010 Nov 18.
Among non-cancer effects of arsenic, cardiovascular diseases have been well documented; however, few are known about the arsenic fate in cardiovascular tissues. We studied the analytic bioinorganic arsenic behaviour in cardiovascular tissues from an arsenic exposure coronary heart disease patient group from Antofagasta-Chile against a small unexposed arsenic coronary heart patient group. Total arsenic concentrations were measured in pieces of cardiovascular tissues of the arsenic-exposed and unexposed coronary heart patient groups by hydride generation atomic absorption spectrometry (HG-AAS); speciation analysis was made by high performance liquid chromatography-inductively coupled plasma-mass spectrometry (HPLC-ICP-MS). Pieces of auricle (AU), mammary artery (MAM), saphenous vein (SAP) and fat residuals (FAT) were considered in this study. The arsenic concentrations in AU and MAM tissues were significantly different between both groups of patients. Also, it was demonstrated that the AU is an 'As(3+) target tissue.' Otherwise, linking of the total concentrations of arsenic with conditional variables and variables related to medical geology factors allowed us to infer that the latter are more important for the cardiovascular risk of arsenic exposure in the Antofagasta region. Knowledge of total arsenic and the prevalence of the trivalent ion (As(3+)) in the AU of patients could contribute to understanding the effect of arsenic on cardiovascular diseases.
在砷的非癌症效应中，心血管疾病已有充分的记录；然而，人们对心血管组织中砷的命运知之甚少。我们研究了来自智利安托法加斯塔砷暴露冠心病患者组与小剂量未暴露砷冠心病患者组的心血管组织中分析生物无机砷的行为。通过氢化物发生原子吸收光谱法（HG-AAS）测量砷暴露和未暴露冠心病患者组心血管组织中总砷浓度；通过高效液相色谱-电感耦合等离子体质谱法（HPLC-ICP-MS）进行形态分析。本研究考虑了耳（AU）、乳内动脉（MAM）、隐静脉（SAP）和脂肪残余物（FAT）。AU 和 MAM 组织中的砷浓度在两组患者之间存在显著差异。此外，还证明 AU 是“As(3+)靶组织”。另外，将砷的总浓度与条件变量和与医学地质因素相关的变量相关联，使我们能够推断出，在后一种情况下，砷暴露对安托法加斯塔地区心血管风险的影响更为重要。了解患者 AU 中的总砷和三价离子（As(3+)）的流行情况有助于了解砷对心血管疾病的影响。
