Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Am J Clin Pathol. 2010 Dec;134(6):873-9. doi: 10.1309/AJCPPPR57HNJMSLZ.
Carbonic anhydrase IX (CAIX), a hypoxia-induced protein, is expressed in some renal tumors. We evaluated its immunohistochemical expression in 317 primary and 42 metastatic renal neoplasms (186 clear cell, 52 papillary, 35 chromophobe, 47 unclassified, and 15 Xp11.2 translocation renal cell carcinomas [RCCs]; 26 oncocytomas; 2 metanephric adenomas; 1 urothelial carcinoma; 1 mixed epithelial and stromal tumor; and 1 angiomyolipoma); 7 neoplasms were unknown as to whether they were primary or metastatic. We also correlated expression with tumor type and grade. Variable staining was seen in clear cell, papillary, unclassified, and Xp11.2 translocation carcinomas. One chromophobe carcinoma had focal expression. No staining was seen with other tumors. An association was found between high expression and clear cell vs non-clear cell carcinomas with all cases (P < .01) and primary (P < .01) cases. An association between CAIX expression and grade (P < .01) in primary clear cell carcinomas was found. CAIX expression is more common in clear cell RCC than other renal tumor types and is associated with grade.
碳酸酐酶 IX（CAIX）是一种缺氧诱导蛋白，在一些肾肿瘤中表达。我们评估了其在 317 例原发性和 42 例转移性肾肿瘤（186 例透明细胞癌、52 例乳头状癌、35 例嫌色细胞癌、47 例未分类癌和 15 例 Xp11.2 易位肾细胞癌[RCC]；26 例嗜酸细胞瘤；2 例后肾腺瘤；1 例尿路上皮癌；1 例混合上皮和间质肿瘤；和 1 例血管平滑肌脂肪瘤）中的免疫组织化学表达；7 例肿瘤未知是原发性还是转移性。我们还将表达与肿瘤类型和分级相关联。在透明细胞癌、乳头状癌、未分类癌和 Xp11.2 易位癌中观察到可变染色。1 例嫌色细胞癌有局灶性表达。其他肿瘤未见染色。高表达与透明细胞癌与非透明细胞癌（所有病例均 P <.01）和原发性病例（P <.01）之间存在关联。在原发性透明细胞癌中，CAIX 表达与分级之间存在关联（P <.01）。CAIX 表达在透明细胞 RCC 中比其他肾肿瘤类型更为常见，并且与分级相关。
