抗抑郁药舍曲林在多发性硬化症实验性自身免疫性脑脊髓炎小鼠模型中的免疫调节作用。
The immunomodulatory effect of the antidepressant sertraline in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis.
机构信息
Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Tel Aviv University, Petah Tikva, Israel.
出版信息
Neuroimmunomodulation. 2011;18(2):117-22. doi: 10.1159/000321634. Epub 2010 Nov 17.
BACKGROUND
We have previously demonstrated the immunomodulatory activity of some selective serotonin reuptake inhibitors.
OBJECTIVES
In this research, we performed an in vivo/ex vivo study to evaluate the potential immunosuppressive effect of sertraline in an experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis.
METHODS
Mice (C57/bl EAE) were treated with sertraline (5 mg/kg) or dexamethasone (1 mg/kg) 7 days after EAE induction and then 3 times weekly (for 3 weeks).
RESULTS
Sertraline modestly improved the clinical score of EAE and attenuated the disease-induced weight loss. Sertraline also significantly decreased ex-vivo splenocyte viability, proliferation and secretion of pro-inflammatory cytokines in EAE mice.
CONCLUSIONS
We suggest that sertraline might be an add-on option for multiple sclerosis treatment.
背景
我们之前已经证明了一些选择性 5-羟色胺再摄取抑制剂的免疫调节活性。
目的
在这项研究中，我们进行了一项体内/体外研究，以评估舍曲林在多发性硬化症的实验性自身免疫性脑脊髓炎（EAE）模型中的潜在免疫抑制作用。
方法
在 EAE 诱导后 7 天，用舍曲林（5mg/kg）或地塞米松（1mg/kg）治疗 C57/bl EAE 小鼠，然后每周 3 次（共 3 周）。
结果
舍曲林轻度改善 EAE 的临床评分，并减轻疾病引起的体重减轻。舍曲林还显著降低了 EAE 小鼠脾细胞的体外活力、增殖和促炎细胞因子的分泌。
结论
我们认为舍曲林可能是治疗多发性硬化症的一种附加选择。
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