Department of Radiology, Korea University Ansan Hospital, 516 Gojan1-dong, Danwon-gu, Ansan, Gyeonggi, 425-707, South Korea.
Neuroradiology. 2011 Sep;53(9):643-9. doi: 10.1007/s00234-010-0798-y. Epub 2010 Nov 19.
The aim of this study was to evaluate the correlation between carotid siphon (CS) calcification and lacunar infarction caused by small-vessel disease.
This retrospective study included 445 patients (M/F = 256:189) older than 40 years (mean age 60.0 ± 12.3 years, range 41-98 years) without large intracranial lesions who had undergone both brain CT and MRI within an interval of 6 months. The patients were classified into three groups according to the number of lacunar infarctions: group I-zero infarctions (n = 328), group II-one to three infarctions (n = 94), and group III-four or more infarctions (n = 23). The severity of CS calcification was evaluated on CT and scored on a five-point scale (0-none, 1-stippled, 2-thin continuous or thick discontinuous, 3-thick continuous, 4-double tracts), and the calcification scores on both sides were summed. An ANOVA test was used to compare calcification scores among the three groups, and a logistic regression test was used to evaluate the influence of CS calcification and known cerebrovascular risk factors on the occurrence of lacunar infarction.
On the ANOVA test, total calcification scores were significantly different among the three groups (group I = 1.28 ± 1.99, group II = 3.31 ± 2.39, group III = 4.36 ± 2.08; P < 0.05). Higher rates of lacunar infarction were associated with higher CS calcification scores. On the logistic regression test, CS calcification, age, and hypertension were significant risk factors for lacunar infarction (P < 0.05).
CS calcification was correlated with the occurrence of lacunar infarction. The degree of CS calcification may be used to predict the possibility of a future lacunar infarction.
本研究旨在评估颈动脉虹吸段（CS）钙化与小血管疾病所致腔隙性梗死之间的相关性。
本回顾性研究纳入了 445 名年龄大于 40 岁（平均年龄 60.0±12.3 岁，范围 41-98 岁）的患者，这些患者在 6 个月内均接受了脑部 CT 和 MRI 检查且无脑内大病灶。根据腔隙性梗死的数量将患者分为三组：I 组无梗死（n=328），II 组 1-3 个梗死（n=94），III 组 4 个或更多梗死（n=23）。CS 钙化的严重程度在 CT 上进行评估，并按照五分制评分（0-无，1-点状，2-细连续或厚不连续，3-厚连续，4-双轨），两侧的钙化评分相加。采用方差分析比较三组间的钙化评分，采用 logistic 回归分析评估 CS 钙化及已知的脑血管危险因素对腔隙性梗死发生的影响。
在方差分析中，三组间总钙化评分有显著差异（I 组 1.28±1.99，II 组 3.31±2.39，III 组 4.36±2.08；P<0.05）。腔隙性梗死的发生率与 CS 钙化评分呈正相关。logistic 回归分析显示，CS 钙化、年龄和高血压是腔隙性梗死的显著危险因素（P<0.05）。
CS 钙化与腔隙性梗死的发生相关。CS 钙化程度可能用于预测未来腔隙性梗死的可能性。
