Wei Ling, Li Yingjie, Tang Yingying, Wang Jijun
School of Communication and Information Engineering, Shanghai University Shanghai 200072, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2010 Oct;27(5):961-7.
Cognitive and emotional dysfunction in depressed patients has been broadly researched. However, the physiological mechanism of the emotional impairment is still obscure. In this study, according to the ethical principles and the procedures of informed consent, we enrolled 16 depression patients and 16 normal subjects in a "learning-judgment" cognitive task. Emotional faces were chosen and used as the visual stimuli, while the subjects' scalp electroencephalographs (EEG) were recorded. We calculated the coherences of the event-related EEG signals between different functional brain regions and used the repeated measure analysis of variance (ANOVA) to analyze the coherences. The results revealed, (1) The depressed patients had a significantly lower inter-hemisphere coherence than did the normal controls at frontal sites across all EEG basic rhythms; (2) The inter-hemispheric coherence of EEG beta activity was significantly correlated with the emotional processing during 1-200 ms after stimulus onset, and the synchronicity with the negative emotion stimulus was higher than that with neutral and positive stimuli; (3) The main effect of race was found at delta and theta bands at about 401-600 ms after stimulus onset. Moreover, the connectivity of inter-hemisphere for own-race stimulus was stronger than that for other-race stimulus.
抑郁症患者的认知和情绪功能障碍已得到广泛研究。然而，情绪损害的生理机制仍不清楚。在本研究中，根据伦理原则和知情同意程序，我们招募了16名抑郁症患者和16名正常受试者参与一项“学习-判断”认知任务。选择情绪面孔作为视觉刺激，并记录受试者的头皮脑电图（EEG）。我们计算了不同功能脑区之间事件相关EEG信号的相干性，并使用重复测量方差分析（ANOVA）来分析相干性。结果显示：（1）在所有EEG基本节律下，抑郁症患者额叶部位的半球间相干性显著低于正常对照组；（2）EEG β活动的半球间相干性与刺激开始后1-200毫秒内的情绪处理显著相关，与负性情绪刺激的同步性高于中性和正性刺激；（3）在刺激开始后约401-600毫秒的δ和θ波段发现了种族的主效应。此外，本种族刺激的半球间连接性强于其他种族刺激。
