Cheng Yunzhang, Luo Binhai, Wu Wenquan, Jiang Lei
University of Shanghai for Science and Technology, Shanghai 200093, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2010 Oct;27(5):1133-7.
The problem of thrombus and hemolysis in blood pump has always been an important topic to study in the development of the blood pump. Numbers of research results show that it is the complicated flow and the high shear stress of the mechanical movement that result in the thrombus and hemolysis. In this study, with the cooperation of Shanghai Children's Medical Center, we have used computational fluid dynamics (CFD) commercial software FLUENT to compute and analyze the flow characteristics in a non-blade centrifugal blood pump. The results figure out that this pump has a reasonable flow distribution and the shear stress distribution is under the critical broken state of red blood cell; meanwhile, there is less thrombus and hemolysis in this pump. So it is in the foreground for clinical use.
血泵中的血栓和溶血问题一直是血泵研发过程中研究的重要课题。大量研究结果表明，是机械运动的复杂流动和高剪切应力导致了血栓和溶血。在本研究中，我们与上海儿童医学中心合作，使用计算流体动力学（CFD）商业软件FLUENT对一款无叶片离心血泵内的流动特性进行了计算分析。结果表明，该血泵具有合理的流动分布，剪切应力分布处于红细胞临界破碎状态以下；同时，该血泵内血栓和溶血较少。因此，其具有临床应用前景。
