Romagnoli C, Tiberi E, Cardiello V, Priolo F, Zecca E
U.O.C. Neonatologia, Policlinico A. Gemelli, Università Cattolica S. Cuore, Roma.
Minerva Pediatr. 2010 Jun;62(3 Suppl 1):113-5.
The aim of this study was to asses the validity of the TCB nomogram for the European population for predicting significant hyperbilirubinemia in healthy term and late-preterm newborns.
This observational study was conducted from February 2009 to December 2009 in the well-baby nurseries of Gemelli hospital of Rome. The predictive ability of the skin bilirubin (TCB) nomogram was prospectively assessed in 926 neonates with gestational age ?35 weeks. TCB was measured with Bilichek and total serum bilirubin (TSB) was contemporary assayed by the standard spectrophotometric method. Every neonate was assess for a single TCB and TSB value.
The mean TSB values was 8.2 +/- 3.2 mg/dl, while the mean TCB values was 9.5 +/- 3.6 mg/dl A sensitivity of 100% and a negative predictive value of 100% were obtained with a single bilirubin determination applying the 75 degrees percentile of our nomogram.
The 75 degrees percentile of the skin bilirubin nomogram for the European population in the first 96 hours of life is able to predict all neonates at risk of severe hyperbilirubinemia. It could facilitate a safe discharge from the hospital and a targeted intervention and follow-up reducing the need for blood samples.
本研究旨在评估用于欧洲人群的经皮胆红素（TCB）列线图预测健康足月儿和晚期早产儿显著高胆红素血症的有效性。
本观察性研究于2009年2月至2009年12月在罗马杰梅利医院的健康婴儿保育室进行。前瞻性评估了926例胎龄≥35周新生儿的经皮胆红素（TCB）列线图的预测能力。使用Bilichek测量TCB，同时采用标准分光光度法测定总血清胆红素（TSB）。对每个新生儿评估单一的TCB和TSB值。
TSB的平均 值为8.2±3.2mg/dl，而TCB的平均值为9.5±3.6mg/dl。应用我们列线图的第75百分位数进行单次胆红素测定，获得了100%的敏感性和100%的阴性预测值。
欧洲人群出生后96小时内经皮胆红素列线图的第75百分位数能够预测所有有严重高胆红素血症风险的新生儿。它有助于安全出院以及有针对性的干预和随访，减少对血标本的需求。
