Institute of Biomaterials and Biomedical Engineering, Department of Medical Biophysics, and Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
Bioconjug Chem. 2010 Dec 15;21(12):2178-82. doi: 10.1021/bc100386a. Epub 2010 Nov 19.
Gold nanoparticle-based surface-enhanced Raman scattering (SERS) probes have shown promise for disease detection and diagnosis. To improve their structural and functional stability for in vivo applications, we synthesized a colloidal SERS gold nanoparticle that encapsulates Raman molecules adsorbed on 60 nm gold with a nonthiol phospholipid coating. Transmission electron microscopy and Raman and UV spectroscopy validated its reproducibility and stability. This novel lipid-based SERS probe provides a viable alternative to the PEGylation and silica coating strategies.
基于金纳米粒子的表面增强拉曼散射（SERS）探针在疾病检测和诊断方面显示出了很大的应用潜力。为了提高其在体内应用的结构和功能稳定性，我们合成了一种胶体 SERS 金纳米粒子，它用非硫醇磷脂将吸附在 60nm 金上的拉曼分子包裹起来。透射电子显微镜、拉曼和紫外光谱验证了其重现性和稳定性。这种新型基于脂质的 SERS 探针为 PEG 化和二氧化硅涂层策略提供了一种可行的替代方法。
