角膜炎症的体内成像：临床实践与研究的新工具。
In vivo imaging of corneal inflammation: new tools for clinical practice and research.
作者信息
Mantopoulos Dimosthenis, Cruzat Andrea, Hamrah Pedram
机构信息
Cornea Service & Ocular Surface Imaging Center, Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
出版信息
Semin Ophthalmol. 2010 Sep-Nov;25(5-6):178-85. doi: 10.3109/08820538.2010.518542.
Abstract
PURPOSE
Infectious and inflammatory corneal diseases are a major cause of blindness. To date, assessment of corneal inflammation, has only been possible by slit-lamp biomicroscopy. The purpose of this study is to review the current state of imaging technologies enabling in vivo imaging of inflammation in the cornea.
METHODS
Literature review of peer-reviewed articles on in vivo imaging modalities.
RESULTS
Current means of diagnosis and treatment follow-up for immune and infectious keratitis are limited to slit-lamp biomicroscopy. Several modalities are currently emerging, allowing for in vivo imaging of corneal inflammation, including in vivo confocal microscopy, anterior segment optical coherence tomography, and intravital multiphoton microscopy.
CONCLUSION
Several in vivo imaging technologies are currently evolving, allowing for objective assessment of corneal inflammation and treatment response.
摘要
目的
感染性和炎症性角膜疾病是失明的主要原因。迄今为止，角膜炎症的评估仅能通过裂隙灯生物显微镜检查来进行。本研究的目的是回顾能够对角膜炎症进行体内成像的成像技术的现状。
方法
对关于体内成像模式的同行评审文章进行文献综述。
结果
目前免疫性和感染性角膜炎的诊断和治疗随访手段仅限于裂隙灯生物显微镜检查。目前正在出现几种模式，可对角膜炎症进行体内成像，包括体内共焦显微镜检查、眼前段光学相干断层扫描和活体多光子显微镜检查。
结论
目前有几种体内成像技术正在发展，能够对角膜炎症和治疗反应进行客观评估。
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