Hebrew University-Hadassah School of Dental Medicine, Department of Oral Medicine, POB 12272, Jerusalem 91120, Israel.
Expert Opin Emerg Drugs. 2010 Dec;15(4):713-26. doi: 10.1517/14728214.2010.528389.
Topical immunomodulators have been used for the management of oral mucosal diseases. Topical immunomodulating preparations may have utility in local management of oral disease which is resistant to topical steroids and oral findings of an immunologic-mediated systemic disease with primary or persisting, oral mucosal involvement.
This paper is the first part of a systematic review of topical immunomodulators for the management of various oral indications focused on calcineurin inhibitors. The literature search revealed that data are available for cyclosporine, tacrolimus and pimecrolimus. In addition to the review of scientific evidence, this paper presents the potential market, the mechanism of action, the competitive environment and future development options.
The reader will find weighted conclusions for the topical use of the calcineurin inhibitors in the management of oral diseases.
Topical calcineurin inhibitors may be useful as a second-line treatment in several oral diseases, particularly oral lichen planus.
局部免疫调节剂已被用于治疗口腔黏膜疾病。局部免疫调节制剂可能对局部治疗有一定作用，如局部治疗对局部类固醇治疗抵抗的疾病，或原发性或持续性口腔黏膜受累的免疫介导的系统性疾病的口腔表现。
这是系统性综述局部免疫调节剂治疗各种口腔适应证的第一部分，重点关注钙调磷酸酶抑制剂。文献检索显示，环孢素、他克莫司和吡美莫司的数据可用。除了科学证据的综述外，本文还介绍了潜在市场、作用机制、竞争环境和未来发展选择。
读者将找到钙调磷酸酶抑制剂局部使用治疗口腔疾病的加权结论。
钙调磷酸酶抑制剂局部制剂可能对几种口腔疾病，特别是口腔扁平苔藓，作为二线治疗有用。
