Berkowitz Robert, Alhaj Eyad, Manchikalapudi Rama Bindu, Satya Kumar, Dadfarmay Sina, Zakir Ramzan
Heart Failure and Pulmonary Hypertension Program, Hackensack Heart and Vascular Institute, Hackensack University Medical Center, Hackensack, NJ 07601, USA.
Congest Heart Fail. 2010 Nov-Dec;16(6):243-8. doi: 10.1111/j.1751-7133.2010.00184.x. Epub 2010 Aug 31.
Pulmonary hypertension, which may lead to right ventricular (RV) failure, increases with left ventricular (LV) diastolic dysfunction severity. The prevalence and determinants of RV failure were analyzed in 120 patients admitted with acute left heart (LH) failure. Patients were divided into RV failure (n=50) and non-RV failure (n=70) groups. The prevalence of RV failure was found to be 42%. In both groups, two thirds of the patients had isolated LV diastolic dysfunction and the rest had combined LV systolic and diastolic dysfunction. Patients in the RV failure group were characterized by higher LV diastolic grade (2.2 ± 0.6 vs 1.84 ± 0.7; P=.0070), pulmonary artery systolic pressure (PASP; 57.8 ± 15.3 vs 50.14 ± 12.1 mm Hg; P=.0028), right atrial enlargement (92% vs 25.7%; P=.000001), and more-than-moderate tricuspid regurgitation (58% vs 27.1%; P=.0006). RV failure is a frequent finding in patients with advanced LH failure. It is strongly associated with the severity of LV diastolic dysfunction and the severity of PASP.
可导致右心室（RV）衰竭的肺动脉高压会随着左心室（LV）舒张功能障碍的严重程度而增加。对120例因急性左心（LH）衰竭入院的患者的右心室衰竭患病率及决定因素进行了分析。患者被分为右心室衰竭组（n = 50）和非右心室衰竭组（n = 70）。发现右心室衰竭的患病率为42%。在两组中，三分之二的患者存在孤立性左心室舒张功能障碍，其余患者存在左心室收缩和舒张功能障碍。右心室衰竭组患者的特征为左心室舒张分级较高（2.2±0.6对1.84±0.7；P = 0.0070）、肺动脉收缩压（PASP；57.8±15.3对50.14±12.1 mmHg；P = 0.0028）、右心房扩大（92%对25.7%；P = 0.000001）以及中重度以上三尖瓣反流（58%对27.1%；P = 0.0006）。右心室衰竭在晚期左心衰竭患者中很常见。它与左心室舒张功能障碍的严重程度和肺动脉收缩压的严重程度密切相关。
