Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA.
J Dig Dis. 2011 Feb;12(1):25-32. doi: 10.1111/j.1751-2980.2010.00473.x.
Portal hypertension is a cause a major luminal gut hemorrhage, most often from esophageal varices. Identification of those with varices, and administration of therapies to reduce the likelihood of initial bleeding improve patient outcomes. Beta blocker therapy or variceal band ligation are most often used in this context. Management of acute variceal hemorrhage (including routine use of antibiotics) is followed by initiating strategies to reduce the frequency of recurrent bleeding. Mortality from portal hypertensive bleeding has been diminished by use of these interventions.
门静脉高压是导致胃肠道大出血的主要原因,最常见的病因是食管静脉曲张。识别那些有静脉曲张的患者,并采取治疗措施降低首次出血的可能性,可以改善患者的预后。在此情况下,β受体阻滞剂治疗或食管静脉曲张套扎术最常被使用。在治疗急性静脉曲张出血(包括常规使用抗生素)后,会开始采取策略来降低再次出血的频率。这些干预措施已经降低了门静脉高压性出血的死亡率。