热敏性不透射线聚（N-异丙基丙烯酰胺-co-聚乙二醇-2-碘苯甲酸酯）的合成与表征

Synthesis and characterization of thermo-sensitive radio-opaque poly(N-isopropylacrylamide-co-PEG-2-iodobenzoate).

作者信息

Lee Bae Hoon, Leon Christine, McLemore Ryan, Macias Jorge Valdez, Vernon Brent L

机构信息

a Harrington Department of Bioengineering, Arizona State University, Tempe, AZ 85287-9709, USA.

出版信息

J Biomater Sci Polym Ed. 2011;22(17):2357-67. doi: 10.1163/092050610X539541.

DOI:10.1163/092050610X539541

PMID:21092424

Abstract

Radiopacity is required for embolic materials to be monitored by angiography during embolization. Covalently bound radio-opaque biomaterials would be ideal for embolization. Poly(N-isopropylacrylamide-co-PEG-acrylate) modified with 2-iodobenzoyl chloride was synthesized and characterized by (1)H-NMR, differential scanning calorimetry and X-ray opacity. Poly(N-isopropylacrylamide-co-PEG-2-iodobenzoate) shows radiopacity, as well as thermo-sensitivity. Cytotoxicity testing on these co-polymers shows little cytotoxicity. Phase-transition temperature and radiopacity varied according to the content of NIPAAm and 2-iodobenzoate. Increasing the content of 2-iodobenzoate raised the radiopacity and lowered the LCST.

摘要

栓塞材料需要具备射线不透性，以便在栓塞过程中通过血管造影进行监测。共价结合的射线不透性生物材料将是栓塞的理想选择。合成了用2-碘苯甲酰氯改性的聚（N-异丙基丙烯酰胺-co-聚乙二醇丙烯酸酯），并通过¹H-NMR、差示扫描量热法和X射线不透性进行了表征。聚（N-异丙基丙烯酰胺-co-聚乙二醇-2-碘苯甲酸酯）具有射线不透性以及热敏感性。对这些共聚物的细胞毒性测试显示细胞毒性很小。相变温度和射线不透性根据NIPAAm和2-碘苯甲酸酯的含量而变化。增加2-碘苯甲酸酯的含量会提高射线不透性并降低最低临界溶解温度。