Quan Mei-ying, Xiang Yang, Wan Xi-run, Feng Feng-zhi
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
Zhonghua Fu Chan Ke Za Zhi. 2010 Sep;45(9):673-6.
To measure the quality of life (QoL) of gestational trophoblastic neoplasia (GTN) survivors after chemotherapy by using a self-invented scale, and to explore the factors associated with QoL.
The design of questionnaire was based on a series of internationally valid QoL scales, which was tested by epidemiology and showed good reliability and validity. A total of 100 survivors of GTN patients from Peking Union Medical College Hospital participated in this survey from December 2008 to May 2009.
Patients with disease-free more than three months after chemotherapy enjoys a good QoL, while only 16% (16/100) of survivors feel general overall QoL, but no one feels bad QoL. As refer to sexual function, more than half of these patients (70%, 70/100) satisfied with their sexual life, while there were still 47% (47/100) and 45% (45/100) of the patients complaining of decreased sexual desire and dryness of vagina. 66% (66/100) of the GTN survivors expressed depression, and 50% (50/100) of patients complained anxiety, which were potential factors influencing QoL of GTN survivors. Relevant analysis explored the possible predictors of QoL for GTN patients, including physical function (r = 0.609, P < 0.01), sexual function (r = 0.473, P < 0.01), and social psychology (r = 0.294, P < 0.01).
GTN survivors have an overall good QoL after chemotherapy, the possible predictors of QoL for GTN patients include physical function, sexual function and social psychology. The sexual dysfunctions mostly present with short of sexual desire and dryness of vagina. Fear of recurrence may be a potential factor influencing QoL a long term after remission.
采用自行编制的量表测量化疗后妊娠滋养细胞肿瘤（GTN）幸存者的生活质量（QoL），并探讨与生活质量相关的因素。
问卷设计基于一系列国际通用的生活质量量表，经流行病学测试，具有良好的信度和效度。2008年12月至2009年5月，共有100例来自北京协和医院的GTN患者幸存者参与了本次调查。
化疗后无病生存超过3个月的患者生活质量良好，仅有16%（16/100）的幸存者感觉总体生活质量一般，但无人感觉生活质量差。在性功能方面，超过一半的患者（70%，70/100）对性生活满意，但仍有47%（47/100）和45%（45/100）的患者抱怨性欲减退和阴道干涩。66%（66/100）的GTN幸存者表示有抑郁情绪，50%（50/100）的患者抱怨有焦虑情绪，这些都是影响GTN幸存者生活质量的潜在因素。相关分析探讨了GTN患者生活质量的可能预测因素，包括身体功能（r = 0.609，P < 0.01）、性功能（r = 0.473，P < 0.01）和社会心理（r = 0.294，P < 0.01）。
GTN幸存者化疗后的总体生活质量良好，GTN患者生活质量的可能预测因素包括身体功能、性功能和社会心理。性功能障碍主要表现为性欲减退和阴道干涩。对复发的恐惧可能是缓解后长期影响生活质量的潜在因素。
