母亲抑郁病史、青少年5HTTLPR基因分型与情绪面孔加工：探索风险机制
Maternal depressive history, teen 5HTTLPR genotype, and the processing of emotional faces: Exploring mechanisms of risk.
作者信息
Jacobs Rachel H, Pine Daniel S, Schoeny Michael E, Henry David B, Gollan Jackie K, Moy Gregory, Cook Edwin H, Wakschlag Lauren S
机构信息
Columbia University, New York State Psychiatry Institute, New York, 10032, United States.
出版信息
Behav Res Ther. 2011 Jan;49(1):80-4. doi: 10.1016/j.brat.2010.10.004. Epub 2010 Oct 28.
Abstract
Variations in the serotonin transporter gene (5HTTLPR) and biased processing of face-emotion displays both have been implicated in the transmission of depression risk, but little is known about developmental influences on these relationships. Within a community sample of adolescents, we examine whether 5HTTLPR genotype moderates the link between maternal depressive history and errors in face-emotion labeling. When controlling for current levels of depression and anxiety among youth, a two-way interaction between maternal depressive history and 5HTTLPR genotype was detected. Specifically, adolescents whose mothers reported a depressive history and who had a low expressing genotype made more errors in classifying emotional faces when compared with adolescents with an intermediate or high expressing genotype, with or without maternal depression history. These findings highlight the complex manner in which maternal depression and genetic risk may interact to predict individual differences in social information processing.
摘要
血清素转运体基因（5HTTLPR）的变异和对面部情绪表达的偏向性加工都与抑郁症风险的传递有关，但对于这些关系的发育影响却知之甚少。在一个青少年社区样本中，我们研究了5HTTLPR基因型是否会调节母亲抑郁病史与面部情绪标签错误之间的联系。在控制了青少年当前的抑郁和焦虑水平后，检测到母亲抑郁病史与5HTTLPR基因型之间存在双向交互作用。具体而言，与具有中等或高表达基因型的青少年相比，无论有无母亲抑郁病史，母亲报告有抑郁病史且具有低表达基因型的青少年在对情绪面孔进行分类时会出现更多错误。这些发现凸显了母亲抑郁和遗传风险可能相互作用以预测社会信息加工中个体差异的复杂方式。
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