Grape King Biotechnology Inc., Chungli, Taiwan.
Food Chem Toxicol. 2011 Feb;49(2):429-33. doi: 10.1016/j.fct.2010.11.018. Epub 2010 Nov 18.
Antrodia cinnamomea (Ac) is a medicinal mushroom widely used for the treatment of abdominal pain, hypertension and hepatocellular carcinoma, but subchronic toxicity of this material has not yet been investigated. This present study was conducted to assess the 90-day oral toxicity of A. cinnamomea from submerged culture in male and female Sprague-Dawley (SD) rats. Eighty rats were divided into four groups, each consisting of ten male and ten female rats. Test articles were administered by oral gavage to rats at 3000, 2200 and 1500 mg/kg BW/day for 90 consecutive days and reverse osmosis water was used as control. All animals survived to the end of the study. During the experiment period, no abnormal changes were observed in clinical signs, body weight and ophthalmological examinations. No significant differences were found in urinalysis, hematology and serum biochemistry parameters between the treatment and control groups. Necropsy and histopathological examination indicated no treatment-related changes. According to the above results, the no-observed-adverse-effect level (NOAEL) of Antrodia cinnamomea is identified to be greater than 3000 mg/kg BW/day in Sprague-Dawley rats.
樟芝（Ac）是一种药用蘑菇，广泛用于治疗腹痛、高血压和肝癌，但该物质的亚慢性毒性尚未得到研究。本研究旨在评估来自液体深层发酵的樟芝在雄性和雌性 Sprague-Dawley（SD）大鼠中的 90 天口服毒性。80 只大鼠分为四组，每组由 10 只雄性和 10 只雌性大鼠组成。试验品通过灌胃给予大鼠，剂量为 3000、2200 和 1500mg/kg BW/day，连续 90 天，反渗水作为对照。所有动物均存活至研究结束。在实验期间，未观察到临床症状、体重和眼科检查的异常变化。治疗组和对照组之间的尿液分析、血液学和血清生化学参数无显著差异。尸检和组织病理学检查未发现与治疗相关的变化。根据上述结果，确定樟芝在 Sprague-Dawley 大鼠中的无观察不良效应水平（NOAEL）大于 3000mg/kg BW/day。
