Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
Exp Hematol. 2011 Feb;39(2):133-41. doi: 10.1016/j.exphem.2010.10.011. Epub 2010 Nov 18.
Gene expression in the eukaryotic cell is regulated at a number of levels, including transcription of genomic DNA into messenger RNA (mRNA), nucleocytoplasmic export of mRNA, and translation of the exported mRNA into proteins in the cytoplasm by ribosomes. The role played by epigenetics and transcription factors associated with the control of gene expression in the developing neutrophil has been well documented and appreciated over the years. A wealth of information on the role played by transcription factors in myeloid biology has contributed to our understanding of both normal and abnormal neutrophil development. However, regulation of mRNA translation in myeloid cell maturation is much less well-studied. A better understanding of the translational control of myeloid gene expression may provide important insights into both normal and abnormal myeloid maturation. This review summarizes our current understanding of the regulation of myeloid gene expression at the mRNA translational level.
真核细胞中的基因表达在多个水平受到调控，包括基因组 DNA 转录成信使 RNA（mRNA）、mRNA 的核质输出以及核糖体在细胞质中将输出的 mRNA 翻译成蛋白质。多年来，人们已经很好地记录和认识到表观遗传学和与控制发育中中性粒细胞基因表达相关的转录因子所起的作用。大量关于转录因子在骨髓生物学中作用的信息有助于我们理解正常和异常中性粒细胞的发育。然而，在骨髓细胞成熟过程中 mRNA 翻译的调节研究得还很少。更好地理解骨髓基因表达的翻译调控可能为正常和异常骨髓成熟提供重要的见解。这篇综述总结了我们目前对 mRNA 翻译水平上骨髓基因表达调控的理解。
