Steele Toby O, Meyers Arlen
Department of Otolaryngology, Head and Neck Surgery, University of California Davis, Sacramento, CA 95817, USA.
Otolaryngol Clin North Am. 2011 Feb;44(1):221-9, vii. doi: 10.1016/j.otc.2010.10.002.
Cancers of the oral cavity account for approximately 3% of malignancies diagnosed annually in the United States. As with other upper aerodigestive tract cancers, 5-year survival rates for oral cavity cancers decrease with delayed diagnosis. Cancers of the oral cavity are thought to progress from premalignant/precancerous lesions, beginning as hyperplastic tissue and developing into invasive squamous cell carcinoma. Despite the general accessibility of the oral cavity during physical examination, many malignancies are not diagnosed until late stages of disease. To prevent malignant transformation of these oral precursor lesions, multiple screening and detection techniques have been developed to address this problem.
口腔癌约占美国每年确诊恶性肿瘤的3%。与其他上消化道癌症一样，口腔癌的5年生存率会随着诊断延迟而降低。口腔癌被认为是从癌前病变发展而来，最初是增生性组织，然后发展成浸润性鳞状细胞癌。尽管在体格检查期间口腔通常易于检查，但许多恶性肿瘤直到疾病晚期才被诊断出来。为了预防这些口腔前驱病变的恶变，已经开发了多种筛查和检测技术来解决这个问题。
