甲型流感致青少年急性自主神经病。

Influenza A induced acute autonomic neuropathy in an adolescent.

机构信息

Department of Pediatrics, Turku University Hospital, Turku, Finland.

出版信息

Pediatr Neurol. 2010 Dec;43(6):425-6. doi: 10.1016/j.pediatrneurol.2010.06.011.

DOI:10.1016/j.pediatrneurol.2010.06.011

Abstract

Influenza A may cause serious neurologic complications, but an autoimmune autonomic ganglionopathy has rarely been reported. Autoantibodies that impair synaptic transmission in the autonomic ganglia may cause orthostatic hypotension, gastrointestinal dysmotility, and sudomotor dysfunction. A 15-year-old girl developed severe and persisting orthostatic hypotension during influenza A infection. Removal of circulating antibodies by a single course of intravenous immunoglobulin resulted in rapid and complete recovery.

摘要

甲型流感可能导致严重的神经系统并发症，但自身免疫性自主神经节病很少见。损害自主神经节突触传递的自身抗体可引起直立性低血压、胃肠动力障碍和出汗功能障碍。一名 15 岁女孩在甲型流感感染期间出现严重且持续的直立性低血压。通过单次静脉注射免疫球蛋白清除循环抗体可迅速完全恢复。