Medical Clinic I, University of Erlangen-Nuremberg, Ulmenweg 18, 91056 Erlangen, Germany.
Gastroenterol Clin North Am. 2010 Dec;39(4):911-22. doi: 10.1016/j.gtc.2010.08.025. Epub 2010 Oct 8.
One of the major proceedings in the field of gastrointestinal endoscopy has been the advent of molecular imaging, which possesses the potential to have a significant effect on the existing diagnostic and therapeutic paradigms. Molecular imaging encompasses different methods that enable the visualization of disease-specific morphologic or functional alterations of the mucosa based on the molecular signature of individual cells. This development has been made possible by advancements in basic science coupled with technological innovations in endoscopy, both facilitating the identification and characterization of mucosal lesions in vivo based on the lesions' molecular composition rather than their morphologic structure alone. Novel studies based on fluorescent antibody imaging pave the road toward clinical translation and give hope for improved diagnosis and targeted therapies in gastrointestinal diseases.
在胃肠内镜领域的主要进展之一是分子成像的出现，它有可能对现有的诊断和治疗模式产生重大影响。分子成像是指不同的方法，能够基于单个细胞的分子特征，可视化黏膜的特定疾病形态或功能改变。这一发展得益于基础科学的进步，以及内镜技术的创新，这两者都有助于根据病变的分子组成而不是仅根据其形态结构来识别和描述黏膜病变。基于荧光抗体成像的新研究为临床转化铺平了道路，并为胃肠道疾病的改善诊断和靶向治疗带来了希望。
