黑色素瘤相关抗原基因——更新。

Melanoma-associated antigen genes - an update.

机构信息

Tumor Research Institute, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050017, PR China.

出版信息

Cancer Lett. 2011 Mar 28;302(2):85-90. doi: 10.1016/j.canlet.2010.10.021. Epub 2010 Nov 19.

DOI:10.1016/j.canlet.2010.10.021

Abstract

To date, dozens of melanoma-associated antigens (MAGE) have been identified. Based on the differences in tissue-specific gene expression and gene structure, the MAGE family has been divided into two big subfamilies: MAGE-I and MAGE-II. MAGE-I genes were identified as a group of highly attractive targets for cancer immunotherapy because of their wide expression in a variety of malignant tumors but silent in normal adult cells except germ-line cells lacking human leukocyte antigen (HLA) expression. However, little is known regarding the functions of MAGE family members in cell activities. In this review, we briefly described the classification of MAGE family members and their expression pattern in cancer. We also summarized the mechanism of MAGE activation and the functions of MAGE family members in cell cycle progression and apoptosis. We also discussed what is known of immunotherapy targeting MAGE family.

摘要

迄今为止，已经鉴定出数十种黑色素瘤相关抗原（MAGE）。根据组织特异性基因表达和基因结构的差异，MAGE 家族已分为两大亚家族：MAGE-I 和 MAGE-II。由于 MAGE-I 基因在多种恶性肿瘤中广泛表达，而在正常成年细胞中除了缺乏人类白细胞抗原（HLA）表达的生殖细胞外则处于沉默状态，因此被鉴定为癌症免疫治疗的一组极具吸引力的靶标。然而，关于 MAGE 家族成员在细胞活动中的功能知之甚少。在这篇综述中，我们简要描述了 MAGE 家族成员的分类及其在癌症中的表达模式。我们还总结了 MAGE 激活的机制以及 MAGE 家族成员在细胞周期进程和细胞凋亡中的功能。我们还讨论了针对 MAGE 家族的免疫疗法的已知情况。