Department of Medicine, White Memorial Medical Center and Loma Linda University School of Medicine, 1720 Cesar Chavez Ave, Los Angeles, CA 90033, USA.
Respir Med. 2011 Feb;105(2):230-5. doi: 10.1016/j.rmed.2010.10.020. Epub 2010 Nov 19.
We performed this study to determine the pulmonary capillary permeability (PCP) measuring radiolabeled human serum albumin leakage into the lung. The objective was to use PCP to differentiate between cardiogenic and non-cardiogenic pulmonary edema etiologies.
We conducted this study in 10 patients admitted to the intensive care unit who had recently developed bilateral pulmonary infiltrates and required hemodynamic monitoring. In these patients we determined the association among the lung permeability index, cardiac output, pulmonary capillary wedge pressure, myocardial performance index, and the protein content of the bronchoalveolar lavage as expressed by bronchoalveolar lavage (BAL) total protein and BAL-to-serum protein ratio. Twenty mCi of technetium-labeled albumin was injected and measure in the heart and the lung at 10 and 180 min post-injection. Lung and heart uptake ratios as well as the lung permeability index were calculated.
We found a good correlation between the lung permeability index and both the myocardial performance index (cardiac output/pulmonary capillary wedge pressure) and the total protein content of the bronchoalveolar lavage fluid.
The lung permeability index is a feasible, noninvasive estimation of the pulmonary capillary permeability.
本研究旨在通过测量放射性标记的人血清白蛋白渗漏入肺来测定肺毛细血管通透性（PCP）。目的是使用 PCP 区分心源性和非心源性肺水肿的病因。
我们对 10 名入住重症监护病房的患者进行了这项研究，这些患者最近出现双侧肺浸润，需要进行血流动力学监测。在这些患者中，我们确定了肺通透性指数、心输出量、肺毛细血管楔压、心肌做功指数以及支气管肺泡灌洗液（BAL）总蛋白和 BAL-血清蛋白比值所表示的支气管肺泡灌洗液（BAL）蛋白含量之间的关系。在注射后 10 和 180 分钟，将 20mCi 的锝标记白蛋白注入心脏和肺部进行测量。计算肺和心脏摄取比以及肺通透性指数。
我们发现肺通透性指数与心肌做功指数（心输出量/肺毛细血管楔压）和支气管肺泡灌洗液总蛋白含量之间存在良好的相关性。
肺通透性指数是一种可行的、非侵入性的肺毛细血管通透性估计方法。
