Society for Biological Research & Rural Development, Lucknow, UP, India.
Infect Genet Evol. 2011 Mar;11(2):308-19. doi: 10.1016/j.meegid.2010.10.013. Epub 2010 Nov 19.
Antigenic drift is the ability of the swine influenza virus to undergo continuous and progressive changes in response to the host immune system. These changes dictate influenza vaccine updates annually to ensure inclusion of antigens of the most current strains. The identification of those peptides that stimulate T-cell responses, termed T-cell epitopes, is essential for the development of successful vaccines. In this study, the highly conserved and specific epitopes from neuraminidase of globally distributed H1N1 strains were predicted so that these potential vaccine candidates may escape with antigenic drift. A total of nine novel CD8(+) T-cell epitopes for MHC class-I and eight novel CD4(+) T-cell epitopes for MHC class-II alleles were proposed as novel epitope based vaccine candidates. Additionally, the epitope FSYKYGNGV was identified as a highly conserved, immunogenic and potential vaccine candidate, capable for generating both CD8(+) and CD4(+) responses.
抗原漂移是猪流感病毒的一种能力，它能够针对宿主免疫系统不断地、持续地发生变化。这些变化要求每年更新流感疫苗，以确保包含当前流行株的抗原。鉴定那些刺激 T 细胞反应的肽，称为 T 细胞表位，对于开发成功的疫苗至关重要。在这项研究中，从全球分布的 H1N1 株的神经氨酸酶中预测了高度保守和特异性的表位，以便这些潜在的疫苗候选物能够逃避抗原漂移。提出了九个新的 MHC Ⅰ类 CD8+T 细胞表位和八个新的 MHC Ⅱ类 CD4+T 细胞表位作为新型表位疫苗候选物。此外，还鉴定出 FSYKYGNGV 表位是一种高度保守、免疫原性和潜在的疫苗候选物，能够产生 CD8+和 CD4+反应。
