INRA, UMR 1079, Système d'Elevage, Nutrition Animale et Humaine, Domaine de la Prise, 35590 Saint Gilles, France.
J Dairy Sci. 2010 Dec;93(12):5842-50. doi: 10.3168/jds.2009-2751.
The aim of this study was to test, in 8 calves fed milk formula based on soybean protein, the ability of sodium butyrate (SB) supplementation to improve nutrient digestibility and daily pancreatic secretions and to modify the kinetics of these secretions. Additionally, effects of duodenal SB infusion were evaluated. Plasma levels of gastrin, secretin, and cholecystokinin were measured. Butyrate supplementation in milk formula increased nutrient digestibility and total daily pancreatic secretions. For juice volume, this increase was most important from 12 to 17h after the morning meal. During the 3-h postprandial period, oral SB supplementation reduced the physiological decrease of postprandial pancreatic secretion (while duodenal digesta flow rate was maximal) and had a minor effect on plasma gut regulatory peptide concentrations. Compared with the diet without SB, ingestion of SB stimulated pancreatic secretion. Taken together, these results could explain the measured increase in nutrient digestibility. The data obtained after duodenal SB infusion did not indicate an effect on pancreatic secretion, apart from elevated lipase output compared with control. The mechanisms responsible for these events are not known and circulating gut regulatory peptides do not seem to be implicated. Our work brings new results regarding SB as a feed additive in young calf nutrition.
本研究旨在检测在 8 头以大豆蛋白为基础的牛奶配方喂养的小牛中，丁酸钠（SB）补充剂提高营养物质消化率和每日胰腺分泌的能力，并改变这些分泌的动力学。此外，还评估了十二指肠 SB 输注的效果。测量了血浆胃泌素、肠促胰酶肽和胆囊收缩素的水平。牛奶配方中添加丁酸盐可提高营养物质消化率和总日胰腺分泌量。对于果汁量，这种增加在早上餐后 12 至 17 小时最为重要。在餐后 3 小时期间，口服 SB 补充剂可减少餐后胰腺分泌的生理性下降（而十二指肠消化物流速最大），并对血浆肠道调节肽浓度有较小的影响。与不含 SB 的饮食相比，摄入 SB 可刺激胰腺分泌。总之，这些结果可以解释所测量的营养物质消化率的增加。与对照相比，十二指肠 SB 输注后的结果除了胰脂肪酶输出增加外，并没有表明对胰腺分泌有影响。这些事件的机制尚不清楚，循环肠道调节肽似乎也没有参与。我们的工作为 SB 作为幼小牛营养的饲料添加剂提供了新的结果。
