Department of Psychiatry, Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA.
Immunol Allergy Clin North Am. 2011 Feb;31(1):109-32. doi: 10.1016/j.iac.2010.09.001.
This review focuses on the contributions of stress-related behavioral factors to cancer growth and metastasis and the biobehavioral mechanisms underlying these relationships. Behavioral factors that are important in modulation of the stress response and the pivotal role of neuroendocrine regulation in the downstream alteration of physiologic pathways relevant to cancer control, including the cellular immune response, inflammation, and tumor angiogenesis, invasion, and cell signaling pathways are described. Consequences for cancer progression and metastasis, as well as quality of life, are delineated. Behavioral and pharmacologic interventions with the potential to alter these biobehavioral pathways for patients with cancer are discussed.
本篇综述聚焦于应激相关行为因素对肿瘤生长和转移的影响，以及这些关系背后的生物行为学机制。描述了在应激反应调节中起重要作用的行为因素，以及神经内分泌调节在与癌症控制相关的生理途径下游改变中的关键作用，包括细胞免疫反应、炎症和肿瘤血管生成、侵袭以及细胞信号转导途径。阐述了这些变化对癌症进展和转移的影响，以及对生活质量的影响。讨论了可能改变癌症患者这些生物行为途径的行为和药物干预措施。
