生物行为因素对癌症进展的影响。
Biobehavioral influences on cancer progression.
机构信息
Department of Psychiatry, Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA.
出版信息
Immunol Allergy Clin North Am. 2011 Feb;31(1):109-32. doi: 10.1016/j.iac.2010.09.001.
Abstract
This review focuses on the contributions of stress-related behavioral factors to cancer growth and metastasis and the biobehavioral mechanisms underlying these relationships. Behavioral factors that are important in modulation of the stress response and the pivotal role of neuroendocrine regulation in the downstream alteration of physiologic pathways relevant to cancer control, including the cellular immune response, inflammation, and tumor angiogenesis, invasion, and cell signaling pathways are described. Consequences for cancer progression and metastasis, as well as quality of life, are delineated. Behavioral and pharmacologic interventions with the potential to alter these biobehavioral pathways for patients with cancer are discussed.
摘要
本篇综述聚焦于应激相关行为因素对肿瘤生长和转移的影响，以及这些关系背后的生物行为学机制。描述了在应激反应调节中起重要作用的行为因素，以及神经内分泌调节在与癌症控制相关的生理途径下游改变中的关键作用，包括细胞免疫反应、炎症和肿瘤血管生成、侵袭以及细胞信号转导途径。阐述了这些变化对癌症进展和转移的影响，以及对生活质量的影响。讨论了可能改变癌症患者这些生物行为途径的行为和药物干预措施。
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本文引用的文献
1
Diurnal cortisol dysregulation, functional disability, and depression in women with ovarian cancer.
Cancer. 2010 Sep 15;116(18):4410-9. doi: 10.1002/cncr.25299.
2
Synergism between immunostimulation and prevention of surgery-induced immune suppression: an approach to reduce post-operative tumor progression.
Brain Behav Immun. 2010 Aug;24(6):952-8. doi: 10.1016/j.bbi.2010.03.010. Epub 2010 Mar 31.
3
Circadian effects in cancer-relevant psychoneuroendocrine and immune pathways.
Psychoneuroendocrinology. 2010 Aug;35(7):963-76. doi: 10.1016/j.psyneuen.2009.12.011. Epub 2010 Jan 22.
4
Age-dependent stimulatory effect of desipramine and fluoxetine pretreatment on metastasis formation by B16F10 melanoma in male C57BL/6 mice.
Pharmacol Rep. 2009 Nov-Dec;61(6):1113-26. doi: 10.1016/s1734-1140(09)70174-4.
5
Fluoxetine induces apoptosis in ovarian carcinoma cell line OVCAR-3 through reactive oxygen species-dependent activation of nuclear factor-kappaB.
Basic Clin Pharmacol Toxicol. 2010 Jun;106(6):446-53. doi: 10.1111/j.1742-7843.2009.00509.x. Epub 2009 Dec 29.
6
Psychosocial adaptation and cellular immunity in breast cancer patients in the weeks after surgery: An exploratory study.
J Psychosom Res. 2009 Nov;67(5):369-76. doi: 10.1016/j.jpsychores.2009.05.016. Epub 2009 Sep 24.
7
Depression as a predictor of disease progression and mortality in cancer patients: a meta-analysis.
Cancer. 2009 Nov 15;115(22):5349-61. doi: 10.1002/cncr.24561.
8
Perioperative pain, psychological distress, and immune function in men undergoing prostatectomy for cancer of the prostate.
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9
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