Institute for Neuroscience and Muscle Research, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.
J Pediatr. 2011 Apr;158(4):660-5. doi: 10.1016/j.jpeds.2010.10.001. Epub 2010 Nov 20.
To examine the mental, motor, and language development of toddlers with neurofibromatosis type 1 (NF1).
In this cross-sectional study, 39 toddlers with NF1 (aged 21-30 months) and 42 age-matched control children were assessed using the Bayley Scales of Infant Development, Second Edition. Basic vocabulary was assessed with the language subtests from the Wechsler Preschool and Primary Scale of Intelligence, Third Edition. Parents completed questionnaires evaluating the children's expressive language, behavior, and executive functioning. The χ(2) test, independent t test, Mann-Whitney U test, and analysis of covariance were used to examine differences between the two groups.
The toddlers with NF1 had significantly poorer mental and motor development than the control participants. Parental responses indicated that most of the children with NF1 had delayed language skills. No differences in behavior and executive functioning were noted between the two groups of children.
Children with NF1 as young as age 30 months demonstrate early signs of mental, motor, and language difficulties. Age 2 years may be the appropriate time to perform an initial developmental assessment to identify mental, motor, and language impairments in children with NF1.
研究 1 型神经纤维瘤病（NF1）患儿的心理、运动和语言发育情况。
在这项横断面研究中，我们使用贝利婴幼儿发展量表第二版评估了 39 名年龄在 21-30 个月的 NF1 患儿和 42 名年龄匹配的对照组儿童。使用韦氏学前和初级智力量表第三版的语言子测验评估基本词汇量。家长完成了评估儿童表达语言、行为和执行功能的问卷。采用卡方检验、独立 t 检验、Mann-Whitney U 检验和协方差分析比较两组间的差异。
NF1 患儿的心理和运动发育明显差于对照组。家长的反馈表明，大多数 NF1 患儿的语言技能发育迟缓。两组患儿的行为和执行功能无差异。
年龄在 30 个月的 NF1 患儿已表现出心理、运动和语言方面的早期困难迹象。2 岁可能是进行初始发育评估以识别 NF1 患儿心理、运动和语言障碍的合适时机。
