Division of Medical Engineering and Materials, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan.
Acta Biomater. 2011 Apr;7(4):1496-503. doi: 10.1016/j.actbio.2010.11.023. Epub 2010 Nov 21.
Two series of poly(ether-ester)-based bis-functional macromers terminated with acrylate groups and a well-defined number of ester bonds were synthesized. One series had a chain of 1, 3 or 5 ester bonds at both ends of the central poly(ethylene glycol) block (molecular weight, about 1000), while the other had an alternating structure of oligo(ethylene glycol) each of them linked to two ester bonds, in which 6 or 10 ester bonds were incorporated equally in the macromer molecules and the total molecular weight was adjusted by about 1000. Irradiation of all poly(ether-ester) macromers mixed with camphorquinone resulted in the formation of gels. Gel yield increased and hydrophilic properties of the gels produced decreased with irradiation time. The elastic modulus of the gels decreased with the number of ester bonds. Upon incubation in a PBS solution (pH 8.04), all gels were gradually degraded with time. At 3 weeks of incubation, the degradation ratio increased linearly with the number of ester bonds per unit of molecular weight of the macromers. The order of in vivo degradation rates determined from weight loss was similar to that of the in vitro study. Thus, these poly(ether-ester) macromers may be useful for biodegradable biomaterials or tissue engineering scaffolds.
两种以丙烯酸酯基团封端且酯键数量明确的聚醚酯基双官能大分子单体被合成。其中一系列在中心聚乙二醇链的两端具有 1、3 或 5 个酯键（分子量约为 1000），而另一系列则具有交替的结构，每个聚乙二醇与两个酯键相连，其中 6 或 10 个酯键均匀地结合在大分子单体中，分子量通过约 1000 来调整。所有聚醚酯大分子单体与樟脑醌混合后进行辐照，会形成凝胶。凝胶产率随着辐照时间的增加而增加，而生成的凝胶的亲水性则降低。凝胶的弹性模量随酯键数量的增加而降低。在 pH 值为 8.04 的 PBS 溶液中孵育时，所有凝胶都会随时间逐渐降解。在孵育 3 周时，降解比例随每单位大分子单体分子量的酯键数量呈线性增加。从失重角度确定的体内降解速率的顺序与体外研究的顺序相似。因此，这些聚醚酯大分子单体可能适用于可生物降解的生物材料或组织工程支架。
