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主动脉根部手术后的生活质量:再植入技术与复合置换。

Quality of life after aortic root surgery: reimplantation technique versus composite replacement.

机构信息

Department of Cardiac and Vascular Surgery, Robert Bosch Hospital, Stuttgart, Germany.

出版信息

Ann Thorac Surg. 2010 Dec;90(6):1869-75. doi: 10.1016/j.athoracsur.2010.07.067.

Abstract

BACKGROUND

Recent studies indicate the safety of the aortic valve reimplantation technique (David operation) in the long-term follow-up. The aim of this study was to compare the results of the David operation with those of the aortic composite replacement procedure, with the focus on quality of life (QoL).

METHODS

Within a 6-year period, 143 patients received either an aortic composite replacement (composite group, n = 67) or the David-I operation (David group, n = 76). The QoL of 108 patients (87% of the living patients) was evaluated postoperatively by the 36-Item Short Form Health Survey. A subgroup analysis of QoL excluded patients with aortic stenosis and type A acute aortic dissection.

RESULTS

Hospital survival rates (89.6% versus 97.4%, p = 0.102), as well as actuarial 1-year survival rate (86.6% versus 91.9%) and 3-year survival rate (81.1% versus 91.9%) proved more successful among the David group. Incidences of serious adverse events during the follow-up period (10.8% versus 28.3%, p = 0.008) were higher for patients of the composite group. The QoL was found to be compromised for patients of the composite group, in relation to all criteria outlined in the 36-Item Short Form Health Survey. Subgroup analysis without patients with dissection and aortic stenosis demonstrated a significantly better postoperative QoL for patients of the David group. Patients belonging to the composite group were more frequently compromised by prosthetic valve noise (p < 0.001).

CONCLUSIONS

This study demonstrates the superiority of the aortic valve reimplantation compared with the aortic composite replacement, regarding both clinical outcome and postoperative QoL.

摘要

背景

最近的研究表明,主动脉瓣再植技术(David 手术)在长期随访中是安全的。本研究旨在比较 David 手术与主动脉复合置换术的结果,重点是生活质量(QoL)。

方法

在 6 年期间,143 例患者接受了主动脉复合置换术(复合组,n = 67)或 David-I 手术(David 组,n = 76)。术后,108 例患者(存活患者的 87%)通过 36 项简短健康调查问卷评估了生活质量。排除了主动脉瓣狭窄和 A 型急性主动脉夹层患者的 QoL 亚组分析。

结果

医院生存率(89.6%比 97.4%,p = 0.102)、1 年生存率(86.6%比 91.9%)和 3 年生存率(81.1%比 91.9%)在 David 组中更成功。复合组患者在随访期间严重不良事件的发生率(10.8%比 28.3%,p = 0.008)更高。复合组患者的生活质量在 36 项简短健康调查问卷中所有标准均较差。无夹层和主动脉瓣狭窄患者的亚组分析显示,David 组患者术后生活质量明显更好。复合组患者因人工瓣膜噪声而受损的频率更高(p < 0.001)。

结论

与主动脉复合置换术相比,本研究表明主动脉瓣再植在临床结局和术后生活质量方面具有优越性。

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