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主动脉瓣环扩张症的外科治疗——置换还是修复?

Surgical Treatment of Annuloaortic Ectasia - Replace or Repair?

作者信息

Martino Andrea De, Re Federico Del, Blasi Stefania, Celiento Michele, Ravenni Giacomo, Pratali Stefano, Milano Aldo D, Bortolotti Uberto

机构信息

Section of Cardiac Surgery, Cardiac Thoracic and Vascular Department, University Hospital, Pisa, Italy.

Division of Cardiac Surgery, University of Verona, Verona, Italy.

出版信息

Aorta (Stamford). 2017 Oct 1;5(5):139-147. doi: 10.12945/j.aorta.2017.17.044. eCollection 2017 Oct.

Abstract

BACKGROUND

Patients with annuloaortic ectasia may be surgically treated with modified Bentall or David I valve-sparing procedures. Here, we compared the long-term results of these procedures.

METHODS

A total of 181 patients with annuloaortic ectasia underwent modified Bentall (102 patients, Group 1) or David I (79 patients, Group 2) procedures from 1994 to 2015. Mean age was 62 ± 11 years in Group 1 and 64 ± 16 years in Group 2. Group 1 patients were in poorer health, with a lower ejection fraction and higher functional class.

RESULTS

Early mortality was 3% in Group 1 and 2.5% in Group 2. Patients undergoing a modified Bentall procedure had a higher incidence of thromboembolism and hemorrhage, whereas those undergoing a David I procedure had a higher incidence of endocarditis. Actuarial survival was 70 ± 6% at 15 years in Group 1 and 84 ± 7% at 10 years in Group 2. Actuarial freedom from reoperation was 97 ± 2% at 15 years in Group 1 and 84 ± 7% at 10 years in Group 2. In Group 2, freedom from procedure-related reoperations was 98 ± 2% at 10 years. At last follow-up, no cases of moderate or severe aortic regurgitation were observed.

CONCLUSIONS

The modified Bentall and David I procedures showed excellent early and late results. The modified Bentall procedure with a mechanical conduit was associated with thromboembolic and hemorrhagic complications, whereas the David I procedure was associated with unexplained occurrences of endocarditis. Thus, the David I procedure appears to be safe, reproducible, and capable of achieving stable aortic valve repair and is therefore our currently preferred solution for patients with annuloaortic ectasia. However, the much shorter follow-up for David I patients limits the strength of our comparison between the two techniques.

摘要

背景

主动脉瓣环扩张患者可通过改良Bentall手术或保留瓣膜的David I手术进行外科治疗。在此,我们比较了这些手术的长期结果。

方法

1994年至2015年,共有181例主动脉瓣环扩张患者接受了改良Bentall手术(102例,第1组)或David I手术(79例,第2组)。第1组患者的平均年龄为62±11岁,第2组为64±16岁。第1组患者的健康状况较差,射血分数较低,心功能分级较高。

结果

第1组的早期死亡率为3%,第2组为2.5%。接受改良Bentall手术的患者血栓栓塞和出血的发生率较高,而接受David I手术的患者心内膜炎的发生率较高。第1组15年的精算生存率为70±6%,第2组10年的精算生存率为84±7%。第1组15年再次手术的精算自由度为97±2%,第2组10年为84±7%。在第2组中,10年与手术相关的再次手术自由度为98±2%。在最后一次随访时,未观察到中度或重度主动脉瓣反流病例。

结论

改良Bentall手术和David I手术均显示出优异的早期和晚期结果。采用机械管道的改良Bentall手术与血栓栓塞和出血并发症相关,而David I手术与不明原因的心内膜炎发生相关。因此,David I手术似乎是安全的、可重复的,并且能够实现稳定的主动脉瓣修复,因此是我们目前治疗主动脉瓣环扩张患者的首选方案。然而,David I手术患者的随访时间短得多,这限制了我们对两种技术比较的力度。

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