Gersch Malte, Sieber Stephan A
Department of Chemistry, Center for Integrated Protein Science Munich (CIPS(M)), Technische Universität München, Lichtenbergstr. 4, 85747 Garching, Germany.
Chem Biol. 2010 Nov 24;17(11):1165-6. doi: 10.1016/j.chembiol.2010.11.003.
In this issue, Puriet al. (2010) present inhibitors that prevent the autocatalytic activation of the clostridial toxin TcdB in vivo. Their approach is likely to provide guidance for the development of novel drugs targeting virulence factors and thereby rendering bacterial pathogens innocuous.
在本期杂志中，普里等人（2010年）介绍了能够在体内阻止梭菌毒素TcdB自催化激活的抑制剂。他们的方法可能会为开发针对毒力因子的新型药物提供指导，从而使细菌病原体无害。
