停顿的意义。

The meaning of pausing.

机构信息

Department of Molecular, Howard Hughes Medical Institute, The University of Colorado at Boulder, 347 UCB, Boulder, CO 80309-0347, USA.

出版信息

Mol Cell. 2010 Nov 24;40(4):507-8. doi: 10.1016/j.molcel.2010.11.025.

DOI:10.1016/j.molcel.2010.11.025

PMID:21095581

Abstract

Pausing of RNA polymerase II (RNAPII) at the 5' end of genes is a widespread phenomenon in metazoans, but the role of this event in gene regulation is poorly understood. Gilchrist et al. (2010) now demonstrate that RNAPII pausing counteracts DNA-influenced nucleosome organization to allow precise gene activation.

摘要

RNA 聚合酶 II（RNAPII）在基因 5' 端的暂停是后生动物中普遍存在的现象，但该事件在基因调控中的作用知之甚少。吉尔克里斯特等人（2010）现在表明，RNAPII 暂停会抵消 DNA 影响核小体组织，从而实现精确的基因激活。