Michel C, Nouvian R, Azevedo-Coste C, Puel J L, Bourien J
INSERM U583 - INM (80 rue Augustin Fliche, 34091 Montpellier - France).
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:722-5. doi: 10.1109/IEMBS.2010.5626273.
Sound translation into neural message at the first auditory synapse is of prime importance for providing organism with sound environment. Here, we compiled experimental features of the primary auditory neurons into a computational model, composed of two distinct compartments (i.e., afferent bouton and axon). Simulation of the model closely reproduces the whole biophysical properties of both excitatory post-synaptic currents and action potentials firing. This simple model provides a powerful tool to understand the synaptic disorders on the sound neural coding at the first auditory synapse.
在第一个听觉突触处将声音准确转换为神经信号对于为生物体提供声音环境至关重要。在此，我们将初级听觉神经元的实验特征整合到一个计算模型中，该模型由两个不同的部分（即传入终扣和轴突）组成。对该模型的模拟紧密再现了兴奋性突触后电流和动作电位发放的整体生物物理特性。这个简单的模型为理解第一个听觉突触处声音神经编码的突触紊乱提供了一个有力工具。
