Charvet G, Billoint O, Gharbi S, Heuschkel M, Georges C, Kauffmann T, Pellissier A, Yvert B, Guillemaud R
CEA/LETI/CLINATEC, Grenoble, France.
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:1804-7. doi: 10.1109/IEMBS.2010.5626403.
In order to understand the dynamics of large neural networks, where information is widely distributed over thousands of cells, one of today's challenges is to successfully monitor the simultaneous activity of as many neurons as possible. This is made possible by using the Micro-Electrode Array (MEA) technology allowing neural cell culture and/or tissue slice experimentation in vitro. Thanks to development of microelectronics' technologies, a novel data acquisition system based on MEA technology has been developed, the BioMEA™. It combines the most advanced MEA biochips with integrated electronics, and a novel user-friendly software interface. To move from prototype (result of the RMNT research project NEUROCOM) to manufactured product, a number of changes have been made. Here, we present a 256-channel MEA data acquisition system with integrated electronics (BioMEA™) allowing simultaneous recording and stimulation of neural networks for in vitro and in vivo applications. This integration is a first step towards an implantable device for BCI (Brain Computer Interface) studies and neural prosthesis.
为了理解大型神经网络的动态特性，其中信息广泛分布在数千个细胞上，当今的挑战之一是成功监测尽可能多的神经元的同步活动。通过使用微电极阵列（MEA）技术实现体外神经细胞培养和/或组织切片实验，这成为可能。得益于微电子技术的发展，基于MEA技术的新型数据采集系统——BioMEA™已被开发出来。它将最先进的MEA生物芯片与集成电子器件以及新颖的用户友好软件界面相结合。为了从原型（RMNT研究项目NEUROCOM的成果）转变为制成品，已做出了一些改变。在此，我们展示一种具有集成电子器件的256通道MEA数据采集系统（BioMEA™），其允许对神经网络进行同步记录和刺激，用于体外和体内应用。这种集成是迈向用于脑机接口（BCI）研究和神经假体的可植入设备的第一步。
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