Roham Masoud, Covey Daniel P, Daberkow David P, Ramsson Eric S, Howard Christopher D, Garris Paul A, Mohseni Pedram
West Wireless Health Institute, La Jolla, CA 92037, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:5322-5. doi: 10.1109/IEMBS.2010.5626345.
This paper reports on a miniaturized device for wireless monitoring of extracellular dopamine levels in the brain of an ambulatory rat using fast-scan cyclic voltammetry at a carbon-fiber microelectrode. The device comprises integrated circuitry for neurochemical recording fabricated in 0.5-microm double-poly triple-metal CMOS technology, which is assembled and packaged on a miniature rigid-flex substrate together with a few external components for supply generation, biasing, and chip programming. The device operates from a single 3-V battery, weighs 2.3 g (including the battery), and upon implantation successfully captures the effects of the psychostimulant amphetamine on electrically and non-electrically evoked dopamine neurotransmission in the caudateputamen region of an ambulatory rat's forebrain.
本文报道了一种小型化装置，该装置利用碳纤维微电极上的快速扫描循环伏安法对自由活动大鼠大脑中的细胞外多巴胺水平进行无线监测。该装置包括采用0.5微米双多晶硅三金属互补金属氧化物半导体（CMOS）技术制造的用于神经化学记录的集成电路，该集成电路与一些用于电源产生、偏置和芯片编程的外部元件一起组装并封装在一个微型刚挠性基板上。该装置由单个3伏电池供电，重2.3克（包括电池），植入后成功捕捉到精神兴奋剂苯丙胺对自由活动大鼠前脑尾状壳核区域电诱发和非电诱发多巴胺神经传递的影响。
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