Faria A D, Lopes A J, Jansen J M, Pinheiro G C, Melo P L
Biomedical Instrumentation Laboratory, Institute of Biology Roberto Alcantara Gomes and Electrical Engineering Faculty, State University of Rio de Janeiro, Brazil.
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:6034-7. doi: 10.1109/IEMBS.2010.5627605.
The objective of this study was to evaluate the clinical potential of the Forced Oscillation Technique (FOT) in the detection of the early alterations in respiratory mechanics of Rheumatoid Arthritis (RA) patients. A total of 36 individuals were analyzed, 18 healthy and 18 with RA. The clinical usefulness of the parameters was evaluated investigating sensibility (Se), specificity (Sp) and the area under the receiver operating characteristic curve (AUC). In the RA group, all the 3 studied parameters obtained high accuracy for clinical use (AUC>0.9), while in spirometric parameters, no parameter obtained appropriate accuracy for clinical use (AUC < 0.7). In conclusion, the parameters obtained by FOT presented adequate Se and Sp, indicating that this technique can be helpful in the evaluation of the early respiratory mechanical alterations in patients with RA.
本研究的目的是评估强迫振荡技术(FOT)在检测类风湿关节炎(RA)患者呼吸力学早期改变方面的临床潜力。共分析了36名个体,其中18名健康个体和18名RA患者。通过研究敏感性(Se)、特异性(Sp)和受试者操作特征曲线下面积(AUC)来评估这些参数的临床实用性。在RA组中,所有3个研究参数在临床应用中均获得了较高的准确性(AUC>0.9),而在肺量计参数中,没有参数在临床应用中获得合适的准确性(AUC<0.7)。总之,FOT获得的参数具有足够的Se和Sp,表明该技术有助于评估RA患者的早期呼吸力学改变。