使用立体粒子图像测速技术对狭窄颈动脉分叉模型进行三维流动表征和剪应力分析

3-D flow characterization and shear stress in a stenosed carotid artery bifurcation model using stereoscopic PIV technique.

作者信息

Kefayati Sarah, Poepping Tamie L

机构信息

Department of Physics and Astronomy, the University of Western Ontario, London, N6A 3K7 Canada.

出版信息

Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:3386-9. doi: 10.1109/IEMBS.2010.5627933.

DOI:10.1109/IEMBS.2010.5627933

PMID:21097242

Abstract

The carotid artery bifurcation is a common site of atherosclerosis which is a major leading cause of ischemic stroke. The impact of stenosis in the atherosclerotic carotid artery is to disturb the flow pattern and produce regions with high shear rate, turbulence, and recirculation, which are key hemodynamic factors associated with plaque rupture, clot formation, and embolism. In order to characterize the disturbed flow in the stenosed carotid artery, stereoscopic PIV measurements were performed in a transparent model with 50% stenosis under pulsatile flow conditions. Simulated ECG gating of the flowrate waveform provides external triggering required for volumetric reconstruction of the complex flow patterns. Based on the three-component velocity data in the lumen region, volumetric shear-stress patterns were derived.

摘要

颈动脉分叉处是动脉粥样硬化的常见部位，动脉粥样硬化是缺血性中风的主要原因。动脉粥样硬化性颈动脉狭窄的影响是扰乱血流模式，产生高剪切率、湍流和再循环区域，这些是与斑块破裂、血栓形成和栓塞相关的关键血流动力学因素。为了表征狭窄颈动脉中的紊乱血流，在脉动流条件下，对一个具有50%狭窄的透明模型进行了立体粒子图像测速（PIV）测量。对流速波形进行模拟心电图门控，为复杂流型的体积重建提供所需的外部触发。基于管腔区域的三分量速度数据，得出了体积剪应力模式。