Lebenberg Jessica, Herard Anne-Sophie, Dubois Albertine, Dhenain Marc, Hantraye Philippe, Delzescaux Thierry
Medical Image Research Center (MIRCen), URA CEA-CNRS 2210, CEA-DSV-I2BM, 18 route du Panorama, F-92265 Fontenay Aux Roses Cedex, France.
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:5636-9. doi: 10.1109/IEMBS.2010.5628043.
Brain glucose uptake was examined in transgenic mice relevant to Alzheimer's disease (APP/PS1) and their control littermates (PS1). Glucose distribution in the brain of the resting animals was measured using 3D-reconstructed autoradiography and analysed by a voxel-wise approach using SPMMouse combined to an MRI-based 3D digital atlas. Prompt and direct indexation of metabolic changes between the two groups was achieved, showing both hypo- and hypermetabolism of glucose in the brain of APP/PS1 mice. We confirm and extend previous study, since we identified brain structures affected in this pathological model and demonstrate glucose uptake changes in structures like the olfactory bulb. Our results pave the way to complete and accurate examination of functional data from cerebral structures involved in models of neurodegenerative diseases.
在与阿尔茨海默病相关的转基因小鼠（APP/PS1）及其对照同窝小鼠（PS1）中检测了脑葡萄糖摄取情况。使用三维重建放射自显影术测量了静息动物大脑中的葡萄糖分布，并通过将SPMMouse与基于MRI的三维数字图谱相结合的体素分析方法进行分析。实现了两组之间代谢变化的快速直接索引，显示APP/PS1小鼠大脑中葡萄糖代谢既有减退又有亢进。我们证实并扩展了先前的研究，因为我们确定了在这个病理模型中受影响的脑结构，并证明了嗅球等结构中的葡萄糖摄取变化。我们的结果为全面准确地检查神经退行性疾病模型中涉及的脑结构的功能数据铺平了道路。
