[2型糖尿病无蛋白尿患者肾小球滤过率相关因素分析]
[Analysis of the factors related to glomerular filtration rate in type 2 diabetes without albuminuria].
作者信息
Lu Xiao-hua, Feng Lie, Jiang Ya-bin, Zhou You-fen
机构信息
Department of Endocrinology, First Affiliated Hospital of Ji'nan University, Guangzhou 510630, China.
出版信息
Nan Fang Yi Ke Da Xue Xue Bao. 2010 Nov;30(11):2502-4.
OBJECTIVE
To analyze the risk factors affecting the glomerular filtration rate (GFR) in type 2 diabetic patients without albuminuria.
METHODS
A total of 131 type 2 diabetic patients with normal urinary albumin excretion rate (UAER) were divided into normal GFR group and decreased GFR group. The factors relevant to GFR were analyzed by multiple factors regression.
RESULTS
Age, course of diabetes, systolic blood pressure, prevalence of hypertension, the level of serum creatinine (SCr), blood urea nitrogen (BUN) and uric acid (UA) were significantly higher in decreased GFR group than in normal GFR group. Multivariate regression showed that SCr, age, systolic blood pressure, and UA were negatively correlated to GFR.
CONCLUSION
Reduced GFR occurs in some type 2 diabetic patients without albuminuria. SCr, age, systolic blood pressure and UA are the major factors related to decreased GFR. The degree of early renal damage in diabetic patients can be better evaluated by combining GFR and UAER.
目的
分析无蛋白尿的2型糖尿病患者肾小球滤过率（GFR）的影响因素。
方法
将131例尿白蛋白排泄率（UAER）正常的2型糖尿病患者分为GFR正常组和GFR降低组。采用多因素回归分析与GFR相关的因素。
结果
GFR降低组的年龄、糖尿病病程、收缩压、高血压患病率、血清肌酐（SCr）、血尿素氮（BUN）和尿酸（UA）水平显著高于GFR正常组。多因素回归显示，SCr、年龄、收缩压和UA与GFR呈负相关。
结论
部分无蛋白尿的2型糖尿病患者存在GFR降低。SCr、年龄、收缩压和UA是与GFR降低相关的主要因素。联合GFR和UAER可更好地评估糖尿病患者早期肾损害程度。
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